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Fig. 4 | Molecular Cancer

Fig. 4

From: miR-4775 promotes colorectal cancer invasion and metastasis via the Smad7/TGFβ-mediated epithelial to mesenchymal transition

Fig. 4

miR-4775 promotes CRC cell invasion and metastasis in vitro and in vivo. a Relative miR-4775 expression in 8 CRC cell lines and one normal colon epithelial line (FHC). b miR-4775 was overexpressed or knocked down by transfecting miR-4775 mimics or anti-miR-4775 vectors (***p < 0.001). c–e Overexpression or knockdown of miR-4775 increased or decreased, respectively, CRC cell wound healing, migration and invasion abilities in vitro (**p < 0.01,***p < 0.001). f–g CRC cells in lung and liver metastases in nude mice. Upregulation and downregulation of miR-4775 increased and decreased, respectively, CRC lung and liver metastases in vivo (**p < 0.01, ***p < 0.001)

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Molecular Cancer

ISSN: 1476-4598