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Fig. 7 | Molecular Cancer

Fig. 7

From: miR-4775 promotes colorectal cancer invasion and metastasis via the Smad7/TGFβ-mediated epithelial to mesenchymal transition

Fig. 7

Roles of Smad7 in miR-4775-mediated tumor progression in vitro. a Overexpressing Smad7 partially weakened the promoting effect of miR-4775 upregulation on SW480 cell wound healing, migration and invasion abilities compared with the control groups (*p < 0.05;**p < 0.01;***p < 0.001). b Knocking down Smad7 partially inhibited the inhibitory effect of miR-4775 downregulation on SW620 cell wound healing, migration and invasion abilities compared with the control group (*p < 0.05;**p < 0.01;***p < 0.001). c Overexpressing or knocking down Smad7 partially reversed the effects of miR-4775 overexpression or knock down on the mRNA levels of EMT markers. d Overexpressing or knocking down Smad7 partially reversed the effects of miR-4775 overexpression or knock down on the protein levels of EMT markers. e Immunofluorescence staining analysis of EMT markers with regard to Smad7 overexpression or knockdown in cells with overexpressing or knocked down for miR-4775 and the corresponding control cells

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Molecular Cancer

ISSN: 1476-4598