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Fig. 1 | Molecular Cancer

Fig. 1

From: Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway

Fig. 1

miR-939 is down-regulated in gastric cancer tissues and cell lines, and inhibits GC proliferation. a comparison miR-939 expression in six GC cell lines and non-transformed epithelial cell line, GES-1. b comparing differences in the expression levels of miR-939 between tumor and corresponding non-tumor tissues. c comparing differences in the expression levels of miR-939 between GC tumor tissues from recurrent and non-recurrent patients. d the predictive value of miR-939 expression regarding the chemotherapy response in 110 patients with advanced GC disease. ROC curve analysis for miR-939 expression was performed to assess GC treatment response (area under the curve [AUC] = 0.777, P < 0.001). e and f MTT assays (e) and colony formation assay (f) indicate that the proliferation and tumorigenicity of miR-939-overexpressing cells was decreased, and that of the miR-939-silenced cells was increased, compared with control cells. Expression levels of miR-939 were determined by qRT-PCR and normalized against an endogenous control (U6 RNA). *P < 0.05, ** P < 0.01

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