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Fig. 1 | Molecular Cancer

Fig. 1

From: Quercetin-induced miR-200b-3p regulates the mode of self-renewing divisions in pancreatic cancer

Fig. 1

PDA cells mostly divide symmetrically. a Schematic illustration of symmetric cell division (SCD) and asymmetric cell division (ACD) in low and high-grade tumorigenesis. b Frozen, human PDA tissue sections were stained for Notch (green), Numb (red) and counterstained with Dapi (blue). The Notch and Numb images were merged using FIJI software. The white arrows mark positive Notch staining on the proliferative sites. c Schematic illustration of SCD and ACD by time-lapse microscopy. d Established PDA cell lines were monitored by time-lapse microscopy under physiologic conditions for a period of 3 divisions and a total of 80 h. The number of visible cells is indicated on each slide

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