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Fig. 2 | Molecular Cancer

Fig. 2

From: Targeting CD133 improves chemotherapeutic efficacy of recurrent pediatric pilocytic astrocytoma following prolonged chemotherapy

Fig. 2

CD133 and MDR1 are present at high levels in recurrent pediatric PAs post chemotherapy. a and b Representative images show CD133 and MDR1 in primary and matched relapsed PAs without (a) and with chemotherapy (b). c Western blots showing protein expression and activation state for PI3K/AKT/NF-κB signaling mediators in primary and matched relapsed PAs, with and without chemotherapy. d Quantification of western blots showing overexpression of CD133 and MDR1 in recurrent PAs with chemotherapy, compared to matched primary tumors. e Overall (top panel) and progression free (bottom panel) survival of PAs without (control group) or with chemotherapy (investigative group)

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