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Fig. 6 | Molecular Cancer

Fig. 6

From: Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells

Fig. 6

Silencing DCLK1 and pro-survival signaling NOTCH1 and RELA reduce the self-renewal ability of human colon cancer cells (DLD1 & HT29). a Protein and mRNA expression levels of DCLK1, NOTCH1, and RELA in the DLD1 and HT29 colon cancer cells transfected with si-DCLK1, si-NOTCH1, and siRELA compared with siScramble-transfected cells. b Self-renewal ability of DLD1 and HT29 cells after the knockdown of DCLK1, NOTCH1, and RELA; bar graph represents the average number of spheroids formed from DLD1 and HT29 cells after the knockdown of DCLK1, NOTCH1, and RELA. All quantitative data are expressed as means ± SD of a minimum of three independent experiments. P values of <0.05 were considered statistically significant

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