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Fig. 1 | Molecular Cancer

Fig. 1

From: Epigenetics in cancer stem cells

Fig. 1

Regulation of key cancer stem cell signaling pathways by epigenetic mechanisms. Wnt/β-catenin signaling can be enhanced by decreased expression of the DKK1 inhibitor through promoter hypermethylation and increased H3K27me3 and decreased H3K16 acetylation marks. Notch signaling target genes such as Hes1 and Hes5 can be activated by inhibition of H3K27 inhibitory methylation mark at their promoter region by STRAP. Hedgehog signaling pathway can be activated in CSCs epigenetically by Shh promoter hypomethylation and increase HDAC1 expression. Epigenetic deregulation of CSC-related signaling pathways allows cancer cells to acquire self-renewal ability and drug resistance properties

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Molecular Cancer

ISSN: 1476-4598