Circular RNAs in human cancer

Table 2 CircRNAs can be novel biomarkers in human cancers

CircRNA	Gene symbol	Alias^a	Chrome position	Types of cancer	Sample numbers (normal/tumor)	Relative clinical characteristics	Methods	Reference
Tissue
hsa_circRNA_100855	C11orf80	hsa_circ_0023028	chr11:66515849-66590145	Progressive laryngeal cancer	56 (4/52)	T classification; Lymph node metastasis, Primary location, Clinical stage	qRT-PCR	[34]
hsa_circRNA_104912	DENND1A	hsa_circ_0088442	chr9:126,438,998-126,641,300	Progressive laryngeal cancer	56 (4/52)	T classification, Differentiation, Lymph node metastasis, Clinical stage	qRT-PCR	[34]
hsa_circ_0001649	SHPRH	hsa_circ_0001649	chr6:146209155-146216113	Hepatocellular carcinoma	178 (89/89)	Tumor size; occurrence of tumor embolus	qRT-PCR	[35]
hsa_circ_001569	ABCC1	hsa_circ_0000677	chr16:16101672-16162159	Colorectal cancer	24 (12/12)	T classification, Distant metastasis	qRT-PCR	[37]
circ VCAN, circ SMO, circ PLOD2, circ GLIS3, circ EPHB4, circ CLIP2, circ PTN,	VCAN;SMO;PLOD2;GLIS3;EPHB4;CLIP2;PTN			Glioma	46 (20/26)	Higher in tumor tissue	RNA seq	[32]
hsa_circ_0005075	EIF4G3	hsa_circ_0005075	chr1:21377358-21415706	Hepatocellular carcinoma	66 (33/33)	Tumor size	qRT-PCR	[36]
Exosome
circ-KLDHC10	KLDHC10	hsa_circ_0082333	chr7:129,756,284-129,762,042	Hepatocellular carcinoma	4 cell line	Higher in CRC serum	RNA seq & qRT-PCR	[33]

ISSN: 1476-4598