assessment of self-renewal | cellular system | |||||
---|---|---|---|---|---|---|
Marker | Known function | References | In vitro | In vivo | cell lines | patients |
CD133 | Regulation of cell membrane topology | [O’Brien et al., 2007] 1 [Ricci-Vitiani et al., 2007] 2 [Todaro et al., 2007] 3 [Vermeulen et al., 2008] 4[Haraguchi et al., 2008] 5 [Ieta et al., 2008] 6 [Wang et al., 2012] 7 [Shmelkov et al., 2008] 8 [Dittfeld et al., 2009] 9 [Fan et al., 2014] 10 [Dubash et al., 2016] 11 [Qureshi-Baig et al., 2016] 12 | 1 ✓ 2 ✓ 3✓ 4 ✓ 6 ✓ 7 ✓ 8 − 9 − 10 − 11 − 12 − | 1 ✓ 2 ✓ 3 ✓ 4 ✓ 5 ✓ 6 ✓ 8 − 9 − 10 − 11 − | 6 7 9 10 | 3 1 2 4 5 8 10 11 12 |
LGR5 | Cell adhesion, intestinal stem cell marker | [Kemper et al., 2012] 1 [Hirsch et al., 2014] 2 [Walker et al., 2011] 3 | 1 ✓ 2 ✓ * 3 – * | 1 ✓ 2 ✓ | 1 2 3 | 1 |
CD44 | Cell adhesion and migration, cell-cell interactions, cell signaling, leukocyte attachment and rolling | [Dalerba et al., 2007] 1 [Vermeulen et al., 2008] 2 [Du et al., 2008] 3 [Haraguchi et al., 2008] 4 [Chu et al., 2009] 5 [Yeung et al., 2010] 6 [Chen et al., 2011] 7 [Wang et al., 2012] 8 [Ohata et al., 2012] 9 | 2✓ 3✓ 5✓ 6✓ 7✓ 8✓ 9✓ | 1✓ 3✓ 4✓ 5✓ 6✓ 7✓ 9✓ | 7 8 | 1 2 3 4 5 6 9 |
CD44v6 | CD44 variant isoform, cell migration and invasion | [Todaro et al., 2014] 1 | 1✓ | 1 | ||
CD24 | B cell proliferation and maturation | [Vermeulen et al., 2008] 1 [Yeung et al., 2010] 2 [Ke et al., 2012] 3 | 1✓ 2✓ 3✓ | 2✓ 3✓ | 2 3 | 1 |
CD166 | Cell adhesion and cell-cell interactions | [Dalerba et al., 2007] 1 | 1✓ | 1 | ||
EpCAM | Cell adhesion, migration, signaling | [Dalerba et al., 2007] 1 | 1✓ | 1 | ||
EphB2 | Position of the different cell types in the crypts | [Merlos-Suárez et al., 2011] 1 | 1✓ | 1 |