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Table 1 Colon TIC markers

From: Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies

    assessment of self-renewal cellular system
Marker Known function References In vitro In vivo cell lines patients
CD133 Regulation of cell membrane topology [O’Brien et al., 2007] 1
[Ricci-Vitiani et al., 2007] 2
[Todaro et al., 2007] 3
[Vermeulen et al., 2008] 4[Haraguchi et al., 2008] 5
[Ieta et al., 2008] 6
[Wang et al., 2012] 7
[Shmelkov et al., 2008] 8
[Dittfeld et al., 2009] 9
[Fan et al., 2014] 10
[Dubash et al., 2016] 11
[Qureshi-Baig et al., 2016] 12
1
2
3
4
6
7
8 −
9 −
10 −
11 −
12 −
1
2
3
4
5
6
8 −
9 −
10 −
11 −
6
7
9
10
3
1
2
4
5
8
10
11
12
LGR5 Cell adhesion, intestinal stem cell marker [Kemper et al., 2012] 1
[Hirsch et al., 2014] 2
[Walker et al., 2011] 3
1
2 *
3 – *
1
2
1
2
3
1
CD44 Cell adhesion and migration, cell-cell interactions, cell signaling, leukocyte attachment and rolling [Dalerba et al., 2007] 1
[Vermeulen et al., 2008] 2
 [Du et al., 2008] 3
[Haraguchi et al., 2008] 4
[Chu et al., 2009] 5
[Yeung et al., 2010] 6
[Chen et al., 2011] 7
[Wang et al., 2012] 8
[Ohata et al., 2012] 9
2
3
5
6
7
8
9
1
3
4
5
6
7
9
7
8
1
2
3
4
5
6
9
CD44v6 CD44 variant isoform, cell migration and invasion [Todaro et al., 2014] 1 1    1
CD24 B cell proliferation and maturation [Vermeulen et al., 2008] 1
[Yeung et al., 2010] 2
[Ke et al., 2012] 3
1
2
3
2
3
2
3
1
CD166 Cell adhesion and cell-cell interactions [Dalerba et al., 2007] 1   1   1
EpCAM Cell adhesion, migration, signaling [Dalerba et al., 2007] 1   1   1
EphB2 Position of the different cell types in the crypts [Merlos-Suárez et al., 2011] 1   1   1
  1. : correlation between self-renewal capacity and expression of surface marker
  2. −: no correlation between self-renewal capacity and expression of surface marker
  3. *: studies based on gene silencing