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Table 1 Colon TIC markers

From: Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies

   

assessment of self-renewal

cellular system

Marker

Known function

References

In vitro

In vivo

cell lines

patients

CD133

Regulation of cell membrane topology

[O’Brien et al., 2007] 1

[Ricci-Vitiani et al., 2007] 2

[Todaro et al., 2007] 3

[Vermeulen et al., 2008] 4[Haraguchi et al., 2008] 5

[Ieta et al., 2008] 6

[Wang et al., 2012] 7

[Shmelkov et al., 2008] 8

[Dittfeld et al., 2009] 9

[Fan et al., 2014] 10

[Dubash et al., 2016] 11

[Qureshi-Baig et al., 2016] 12

1 ✓

2 ✓

3✓

4 ✓

6 ✓

7 ✓

8 −

9 −

10 −

11 −

12 −

1 ✓

2 ✓

3 ✓

4 ✓

5 ✓

6 ✓

8 −

9 −

10 −

11 −

6

7

9

10

3

1

2

4

5

8

10

11

12

LGR5

Cell adhesion, intestinal stem cell marker

[Kemper et al., 2012] 1

[Hirsch et al., 2014] 2

[Walker et al., 2011] 3

1 ✓

2 ✓ *

3 – *

1 ✓

2 ✓

1

2

3

1

CD44

Cell adhesion and migration, cell-cell interactions, cell signaling, leukocyte attachment and rolling

[Dalerba et al., 2007] 1

[Vermeulen et al., 2008] 2

 [Du et al., 2008] 3

[Haraguchi et al., 2008] 4

[Chu et al., 2009] 5

[Yeung et al., 2010] 6

[Chen et al., 2011] 7

[Wang et al., 2012] 8

[Ohata et al., 2012] 9

2✓

3✓

5✓

6✓

7✓

8✓

9✓

1✓

3✓

4✓

5✓

6✓

7✓

9✓

7

8

1

2

3

4

5

6

9

CD44v6

CD44 variant isoform, cell migration and invasion

[Todaro et al., 2014] 1

1✓

  

1

CD24

B cell proliferation and maturation

[Vermeulen et al., 2008] 1

[Yeung et al., 2010] 2

[Ke et al., 2012] 3

1✓

2✓

3✓

2✓

3✓

2

3

1

CD166

Cell adhesion and cell-cell interactions

[Dalerba et al., 2007] 1

 

1✓

 

1

EpCAM

Cell adhesion, migration, signaling

[Dalerba et al., 2007] 1

 

1✓

 

1

EphB2

Position of the different cell types in the crypts

[Merlos-Suárez et al., 2011] 1

 

1✓

 

1

  1. ✓: correlation between self-renewal capacity and expression of surface marker
  2. −: no correlation between self-renewal capacity and expression of surface marker
  3. *: studies based on gene silencing