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Table 4 Validity estimates for miR’s promoter methylation as markers for PCa in Cohort #1

From: MiR-193b promoter methylation accurately detects prostate cancer in urine sediments and miR-34b/c or miR-129-2 promoter methylation define subsets of clinically aggressive tumors

microRNA

Sensitivity % (n positive/n total)

Specificity (%)

PPV (%)

NPV (%)

Accuracy (%)

miR-34b/c

94.4 (170/180)

86.7

98.8

56.5

93.8

miR-129-2

90.6 (163/180)

86.7

98.8

43.3

90.3

miR-152

79.4 (143/180)

86.7

98.6

26.0

80.0

miR-193b

90.0 (162/180)

100.0

100.0

45.5

90.8

miR-663a

84.4 (152/180)

100.0

100.0

34.9

85.6

miR-1258

97.8 (176/180)

100.0

100.0

78.9

97.9

  1. PCa Prostate cancer; PPV positive predictive value; NPV negative predictive value