Fig. 2

Data heatmaps and histograms showing expression of homeobox genes in the TCGA (RNASeq and PAM50) and METABRIC datasets. Genomic heatmaps compare expression of genes between normal and tumour samples, with yellow and blue colour intensity indicating high and low expression, respectively. The red and green colours under the genomic heatmaps indicate the statistics track showing the logarithmic plot of P-values for each gene using Student’ t-test followed by Bonferroni’s correction. Bars above the line indicates that the red subgroup (Tumour sample) is greater than the green subgroup; a bar below the line indicates that the green subgroup (Normal sample) is greater than the red subgroup. Bars are coloured in red or green when P < 0.05. The same colour code summarises the same information obtained from analysis of the METABRIC and PAM50 datasets (Additional file 3: Figure S2) and the homeobox PCR array (Fig. 1) in the tables below the heatmaps. a. Homeobox genes differentially expressed in CSC of all cancer subtypes. b. Homeobox genes differentially expressed in LUM CSC. c. Homeobox genes differentially expressed in HER2-E CSC. d. Homeobox genes differentially expressed in TN CSC