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Table 1 OPG mRNA expression is significantly correlated to CCL2 and IL1B mRNA expression in breast cancer

From: Osteoprotegerin mediates tumor-promoting effects of Interleukin-1beta in breast cancer cells

Dataset

CCL2

IL1B

 

R

P

R

P

Bertucci - 266

0.269

8.8 • 10−6

0.177

3.8 • 10−3

Bos - 204

0.330

1.4 • 10−6

0.193

5.8 • 10−3

Chin-124

0.232

9.5 • 10−3

0.207

0.02

EXPO Breast - 351

0.153

4.2 • 10−3

0.200

1.6 • 10−4

Halfwerk - 947

0.077

0.02

n.s.

Iglehart-123

0.227

0.01

0.200

0.03

Miller-251

0.150

0.02

n.s.

Servant - 343

0.199

2.0 • 10−4

0.252

2.4 • 10−6

Smid - 210

0.312

4.0 • 10−6

0.198

4.0 • 10−3

TCGA Breast - 528

0.236

4.3 • 10−8

0.197

5.3 • 10−6

TCGA Breast - 1097

0.210

2.3 • 10−12

0.253

1.9 • 10−17

Wang - 286

0.212

3.1 • 10−4

0.165

5.1 • 10−3

Zhang - 136

0.293

5.3 • 10−4

0.295

5.0 • 10−4

 

13 of 13

11 of 13

  1. OPG and CCL2/IL1B mRNA expression and correlation were analyzed in 13 human breast cancer datasets (See Materials and Methods). Columns from left to right: Dataset name (and sample size), OPG-CCL2 correlation (r = correlation, p = p value; significant and positive in all 13 datasets), and OPG-IL1B correlation (significant and positive in 11 of 13 datasets). Correlations were calculated using a 2log Pearson test
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Molecular Cancer

ISSN: 1476-4598