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Fig. 4 | Molecular Cancer

Fig. 4

From: Doxycycline attenuates breast cancer related inflammation by decreasing plasma lysophosphatidate concentrations and inhibiting NF-κB activation

Fig. 4

Doxycycline (Dox) significantly decreased the secretion of IL-6, CCL2 and CXCL2 by 4T1 cells. Cells were cultured with DMEM/10% FBS. The medium was changed with DMEM/0.1% BSA with or without LPA (5 μM) and Dox (5 μg/ml or 10 μg/ml). Conditioned medium was collected after incubation for another 24 h. Measurements were normalized to the cell protein. * p < 0.05 relative to cells without Dox and LPA treatment, # p < 0.05 relative to cells treated with LPA but not Dox. Results are means ± SEM from three independent experiments. Results were analyzed by ANOVA with an SNK posthoc test

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Molecular Cancer

ISSN: 1476-4598