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Table 2 Summary of the profiles of ALK and its related molecules in 27 uterine carcinosarcoma cases

From: Functional role of ALK-related signal cascades on modulation of epithelial-mesenchymal transition and apoptosis in uterine carcinosarcoma

     ALK   Sox11 N-myc pAkt Twist1 bcl2
Case Age Histology IHC ISH FISH IHC IHC IHC IHC IHC
No. (year) Ca Sa Ca Sa Ca Sa   Ca Sa Ca Sa Ca Sa Ca Sa Ca Sa
UCS 1 59 Non-E Homo 0 0 1+ a 2 0 0 0 2 0 8 0 12 2
UCS 2 60 Non-E Het (con) 0 0 a a a 0 0 a a a a a a
UCS 3 61 E Homo 0 0 a a a 0 0 0 0 2 0 4 0 0 0
UCS 4 81 E Het (con) 2 0 1+ a 3 0 0 0 4 4 6 2 8 8
UCS 9 58 E Homo 0 0 N 3+ a a a a a a a a a 2 4
UCS 10 85 E Homo 0 0 3+ 3+ a 0 2 0 0 2 6 0 9 0 0
UCS 19 59 E Homo 0 0 a 0 0 0 0 4 4 3 12 0 0
UCS 12 76 E Homo 0 0 3+ N a 0 0 0 0 0 8 0 4 3 3
UCS 22 58 E Homo 0 0 2+ a 0 0 0 0 0 0 0 0 0 0
UCS 25 74 E Homo 0 2 1+ 1+ a a a a a a a a a 0 0
UCS 26 78 Non-E Het (con) 0 0 1+ a 0 0 0 0 2 2 0 0 a a
UCS 27 65 E Homo 0 2 1+ 1+ a 0 0 0 0 0 2 0 6 a a
UCS 29 73 E Het (Rha) 0 0 3+ a 0 0 0 0 0 0 0 6 4 4
UCS 33 51 E Homo 0 12 a a a a 0 0 2 0 a a a a
UCS 35 67 E Homo 0 4 3+ 2+ a 0 0 0 0 0 2 0 4 a a
UCS 36 57 E Homo 0 0 N a 0 0 0 0 2 2 0 0 4 8
UCS 37 69 E Homo 0 6 3+ 0 0 0 0 0 0 0 2 0 4
UCS 38 59 Non-E Homo 0 4 a a a 0 0 0 0 2 4 0 8 0 2
UCS 39 76 E Homo 0 4 2+ 2+ a 0 0 0 4 4 4 0 6 4 4
UCS 42 63 Non-E Homo 0 0 a 0 0 0 0 2 6 0 2 0 0
UCS 44 50 Non-E Homo 0 0 1+ a 0 0 0 0 2 2 0 6 0 0
UCS 45 75 E Het (Rha) 0 0 a 0 0 0 0 4 0 0 4 0 8
UCS 46 68 E Het (con) 0 0 2+ 1+ a 4 0 2 0 6 6 0 12 8 2
UCS 47 69 Non-E Homo 9 0 1+ 1+ 4 8 a a 2 0 0 8 8 8
UCS 48 54 E Homo 0 0 a a a 0 0 0 0 0 0 0 2 0 4
UCS 51 59 E Homo 8 4 a a 4 3 3 0 3 3 0 2 6 6
UCS 52 49 E Homo 6 0 a a 6 0 0 0 0 0 12 0 a a
  1. Abbreviations: No. number, Ca carcinomtous component, Sa sarcomatous component, IHC immunohistochemistry, ISH in situ hybridization, FISH Fluorescence in situ hybridization, Non-Enon endometrioid, E endometrioid, Homo homologus, Het heterologous, con condrosarcoma, Rha rhabdomyosarcoma
  2. anot examined; FISH -, no rearrangement ot amplification of ALK locus