Functional role of ALK-related signal cascades on modulation of epithelial-mesenchymal transition and apoptosis in uterine carcinosarcoma

Table 2 Summary of the profiles of ALK and its related molecules in 27 uterine carcinosarcoma cases

				ALK					Sox11		N-myc		pAkt		Twist1		bcl2
Case	Age	Histology		IHC		ISH		FISH	IHC		IHC		IHC		IHC		IHC
No.	(year)	Ca	Sa	Ca	Sa	Ca	Sa		Ca	Sa	Ca	Sa	Ca	Sa	Ca	Sa	Ca	Sa
UCS 1	59	Non-E	Homo	0	0	1+	–	^a	2	0	0	0	2	0	8	0	12	2
UCS 2	60	Non-E	Het (con)	0	0	–	–	^a	^a	^a	0	0	^a	^a	^a	^a	^a	^a
UCS 3	61	E	Homo	0	0	^a	^a	^a	0	0	0	0	2	0	4	0	0	0
UCS 4	81	E	Het (con)	2	0	1+	−	^a	3	0	0	0	4	4	6	2	8	8
UCS 9	58	E	Homo	0	0	N	3+	^a	^a	^a	^a	^a	^a	^a	^a	^a	2	4
UCS 10	85	E	Homo	0	0	3+	3+	^a	0	2	0	0	2	6	0	9	0	0
UCS 19	59	E	Homo	0	0	−	−	^a	0	0	0	0	4	4	3	12	0	0
UCS 12	76	E	Homo	0	0	3+	N	^a	0	0	0	0	0	8	0	4	3	3
UCS 22	58	E	Homo	0	0	−	2+	^a	0	0	0	0	0	0	0	0	0	0
UCS 25	74	E	Homo	0	2	1+	1+	^a	^a	^a	^a	^a	^a	^a	^a	^a	0	0
UCS 26	78	Non-E	Het (con)	0	0	–	1+	^a	0	0	0	0	2	2	0	0	^a	^a
UCS 27	65	E	Homo	0	2	1+	1+	^a	0	0	0	0	0	2	0	6	^a	^a
UCS 29	73	E	Het (Rha)	0	0	3+	–	^a	0	0	0	0	0	0	0	6	4	4
UCS 33	51	E	Homo	0	12	^a	^a	–	^a	^a	0	0	2	0	^a	^a	^a	^a
UCS 35	67	E	Homo	0	4	3+	2+	^a	0	0	0	0	0	2	0	4	^a	^a
UCS 36	57	E	Homo	0	0	–	N	^a	0	0	0	0	2	2	0	0	4	8
UCS 37	69	E	Homo	0	6	–	3+	–	0	0	0	0	0	0	0	2	0	4
UCS 38	59	Non-E	Homo	0	4	^a	^a	^a	0	0	0	0	2	4	0	8	0	2
UCS 39	76	E	Homo	0	4	2+	2+	^a	0	0	0	4	4	4	0	6	4	4
UCS 42	63	Non-E	Homo	0	0	−	−	^a	0	0	0	0	2	6	0	2	0	0
UCS 44	50	Non-E	Homo	0	0	−	1+	^a	0	0	0	0	2	2	0	6	0	0
UCS 45	75	E	Het (Rha)	0	0	−	−	^a	0	0	0	0	4	0	0	4	0	8
UCS 46	68	E	Het (con)	0	0	2+	1+	^a	4	0	2	0	6	6	0	12	8	2
UCS 47	69	Non-E	Homo	9	0	1+	1+	−	4	8	^a	^a	2	0	0	8	8	8
UCS 48	54	E	Homo	0	0	^a	^a	^a	0	0	0	0	0	0	0	2	0	4
UCS 51	59	E	Homo	8	4	^a	^a	−	4	3	3	0	3	3	0	2	6	6
UCS 52	49	E	Homo	6	0	^a	^a	−	6	0	0	0	0	0	12	0	^a	^a

Abbreviations: No. number, Ca carcinomtous component, Sa sarcomatous component, IHC immunohistochemistry, ISH in situ hybridization, FISH Fluorescence in situ hybridization, Non-Enon endometrioid, E endometrioid, Homo homologus, Het heterologous, con condrosarcoma, Rha rhabdomyosarcoma
^anot examined; FISH -, no rearrangement ot amplification of ALK locus

ISSN: 1476-4598