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Fig. 2 | Molecular Cancer

Fig. 2

From: Cdk5 links with DNA damage response and cancer

Fig. 2

The activation of Cdk5 is regulated by modulation of p35 in different levels. In transcriptional level, the transcription factors Egr1, Brn-1 and Brn-2 can bind to the promoter of p35 gene and positively regulate its mRNA expression. After transcription, the binding of nELAV to p35 mRNA 3’-UTR can positively control its mRNA stability, while hnRNPA2/B1, miR-103 and miR-107 have a negative effect resulting in mRNA destabilization. Post-translational protein modifications of p35, sumoylation and S-nitrosylation, can respectively increase and restrain Cdk5 activity. The over-expression of two small peptides derived as truncations of p35, CIp and p5, can selectively inhibit Cdk5/p25 hyper-activation without affecting endogenous Cdk5/p35 activity

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