Table 2 The SWI/SNF complex affects cancer development by regulating oncogene expression
From: Linking long non-coding RNAs and SWI/SNF complexes to chromatin remodeling in cancer
SWI/SNF | Interaction of SWI/SNF with oncogene | Cancer types/Phenotypes | Refs |
|---|---|---|---|
BRG1 | BRG1 promotes myc transcription and maintenance of oncogenic programming. | Leukemia | [52] |
BRG1 | BRG1 directly recruits to the MAX (myc-associated factor X gene) promoter and regulates the expression of MAX. | Lung cancer | [54] |
SNF5/INI1 | SNF5/INI1 interacts with c-myc and recruits the SWI/SNF complex, which contributes to the transcription of MYC target genes. | Apoptosis | [50] |
BAF250A | BAF250A subunit directly inhibits the expression of MYC. | Differentiation associated cell cycle arrest | [51] |
BAF155 | Methylated BAF155 recruited to MYC target gene, GADD45A. | Breast cancer progression and metastasis | [49] |
BRG1 | BRG1 inactivating mutation may cooperate with KRAS mutation during carcinogenesis. | Lung Cancer | [57] |
BRM, BRG1, hSNF5, BAF250A | The RAS inhibitor RasGAP1 can inhibit the BRM, knockdown SWI/SNF members BRM, BRG1, hSNF5 and BAF250A, and decrease the active KRAS | Colon cancer cell | [56] |
BRG1 | BRG1 inactivating mutation cooperates with oncogenic KRAS and promote the progression of pancreatic ductal adenocarcinoma. | Pancreatic ductal adenocarcinoma | [59] |
SNF5 | SNF5 can bind and activate the tumor repressor INK4A/ARF, which is in response to oncogene KRAS, indicating that the function of SWI/SNF link to oncogene KRAS. | Lung tumor | [58] |