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Fig. 3 | Molecular Cancer

Fig. 3

From: KCNMA1 cooperating with PTK2 is a novel tumor suppressor in gastric cancer and is associated with disease outcome

Fig. 3

In vitro gain-function assays on KCNMA1. a Ectopic expression of KCNMA1 in BGC803 and MGC823 cells at mRNA and protein levels was confirmed by RT-PCR and western blot analysis. b KCNMA1 significantly inhibited cell viability. c Representative images of invasion assays for BGC803 and MGC823 cells transfected with control and KCNMA1 vector, error bars, s.d. n = 3 technical replicates. d Representative images of a migration assay for BGC803 and MGC823 cells transfected with control and KCNMA1 vector, error bars, s.d. n = 3 technical replicates. e KCNMA1 significantly inhibited cell colony formation ability. f KCNMA1 induces the apoptosis of BGC803 and MGC-823. (F_left) The cells were cultured for 48 h, the level of apoptosis was determined by flow cytometry, representative data from one of the three experiments was shown. (F_right) After MGC-823 transfected with KCNMA1, UR percentage + LR percentage in NC are less than cell treat with KCNMA1.*P < 0.01

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