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Fig. 4 | Molecular Cancer

Fig. 4

From: KCNMA1 cooperating with PTK2 is a novel tumor suppressor in gastric cancer and is associated with disease outcome

Fig. 4

The association between KCNMA1 and PTK2, and Repeating observation on malignant cell behavior after co-transfected with NC, KCNMA1 vector and si-PTK2. a The expression of PTK2 in gastric carcinoma and paired corresponding normal tissues. b Expression levels of KCNMA1 and PTK2 in tissues were significantly correlated in a negative direction. c The correlation of KCNMA1 and PTK2 was verified in GEO (GSE29272). d The KCNMA1 suppress the expression of PTK2, and the relation were identified in BGC803 and MGC823 cells at mRNA and protein levels was confirmed by RT-PCR and western blot analysis. Inhibitory role of KCNMA1 on malignant cell phenotype, i.e. e invasion and migration; f proliferation and (g) colony formation; was diminished after PTK2 was knockdown.*P < 0.01, ** P < 0.001

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