Fig. 2

Osteolytic bone disease is increased in myeloma-bearing MMP-7-deficient mice. Wild-type (WT) or MMP-7 homozygous deficient (MMP-7^−/−) mice were inoculated with 5TGM1 myeloma cells (MM) or vehicle control. MicroCT analysis demonstrated that trabecular bone volume was decreased (a) and osteolytic lesions were increased (b) in myeloma bearing MMP-7^−/− mice, as compared to myeloma bearing WT mice. Histomorphometric analysis demonstrated an increase in osteoclasts (c) and a decrease in osteoblasts (d) in myeloma-bearing WT and MMP-7−/− mice as compared to control. Data represent mean ± SEM. Mann Whitney U test *p < 0.05, **p < 0.01, ***p < 0.001 (WT, n = 7; MMP-7^−/−, n = 4; WT + MM, n = 8; MMP-7^−/− + MM, n = 5)