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Fig. 2 | Molecular Cancer

Fig. 2

From: Vasohibin 2 reduces chemosensitivity to gemcitabine in pancreatic cancer cells via Jun proto-oncogene dependent transactivation of ribonucleotide reductase regulatory subunit M2

Fig. 2

VASH2 decreases the sensitivity of pancreatic cancer cells to gemcitabine in vitro. After treatment with 25 or 50 nM gemcitabine for 48 h, the apoptosis rate of PANC-1-EGFP, PANC-1-VASH2, SW1990-scramble, and SW1990-shVASH2 was indicated by flow cytometric determination of Annexin V and 7-AAD staining. Upper-right + lower-right quadrants indicate apoptotic cells. Apoptosis is quantified in the bar graphs for PANC-1-EGFP and PANC-1-VASH2 (top) and SW1990-scramble and SW1990-shVASH2 (bottom). *P < 0.05

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