MicroRNA-29c functions as a tumor suppressor by targeting VEGFA in lung adenocarcinoma

Table 2 Results of the univariate and multivariate analyses of prognostic factors for OS

	Univariate analysis			Multivariate analysis
Characteristic	MST (mos)	5-y OS (%)	p-value	HR	95% CI	p-value
Age			0.394
< 60 y	31.3	29.8
≥ 60 y	37.9	35.0
Sex			0.850
Male	34.6	30.0
Female	36.7	35.1
ECOG performance status			0.987
0	36.7	30.0
1	34.0	34.0
Weight loss			0.593
≤ 5%	37.9	32.5
> 5%	31.6	25.0
Smoking status			0.364
Smokers	34.6	25.8
Nonsmokers	36.7	35.7
Tumor stage			0.005			0.033
1	43.8	50.0		0.456	0.167–1.248	0.126
2	40.7	35.4		0.441	0.237–0.818	0.009
3	15.9	6.7
Number of N2 station			0.029	0.654	0.387–1.104	0.112
Single	49.3	38.2
Multiple	26.9	25.0
Postoperative chemotherapy			0.629
Yes	34.2	31.5
No	43.8	36.4
Postoperative radiotherapy			0.318
Yes	31.3	22.2
No	40.7	34.7
MiR-29c expression			<0.001	3.694	2.106–6.479	<0.001
Low	25.1	6.8
High	68.9	58.1

Abbreviations: OS overall survival, MST median survival time, mos months, HR hazard ratio, CI confidence interval

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