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Fig. 7 | Molecular Cancer

Fig. 7

From: Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways

Fig. 7

Expression of Notch-1 & -3 transcript levels and their correlation with Syndecan-1 mRNA expression in clinical samples of IBC vs non-IBC patients. a Scatter plot shows a significant upregulation of Notch-1 mRNA (left panel) but not Notch-3 mRNA levels (right panel) in tissues of IBC (n = 13) vs non-IBC (n = 14). RQ values of mRNA expression are log2-transformed and normalized to values of normal tissues collected during reduction mammoplasty. Bars represent median with interquartile range. ** P < 0.01 as determined by Mann-Whitney U-test. b Pearson’s correlation between Syndecan-1 and Notch-1 mRNA expression in tissues of in non-IBC (left panel) and IBC (right panel) c Pearson’s correlation between Syndecan-1 and Notch-3 mRNA expression in tissues of non-IBC (left panel) and IBC (right panel)

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Molecular Cancer

ISSN: 1476-4598