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Fig. 2 | Molecular Cancer

Fig. 2

From: Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways

Fig. 2

Increased expression of CXCL5 in CRC tissues, Kaplan-Meier analysis and nomogram plots. a & b RT-PCR results showing high expression of CXCL5 in CRC tissues. Data are showed by 2-ΔΔCt (a) and 2-ΔCt (b). c & d Representative immunohistochemistry images showing that CXCL5 is highly expressed in 61.5% of the cancer tissues in tissue microarray (tissues used are different from Figs. 1 and 2a & b). Scale: 200 μm. ***P<0.001. e & f Kaplan-Meier analysis of OS and DFS. The CXCL5high group has a worse prognosis in OS and DFS compared with the CXCL5low group. g Nomogram to predict DFS 3 and 5 years after surgery. CXCL5 line: 1 represents positive staining; 0 represents negative staining. Stage line: 1, 2, 3 and 4 represent Dukes stage I, II, III and IV. Calculation: find their points on the “point line” according to the CXCL5 staining and Dukes stage. Total points are equal to CXCL5 points plus Dukes stage points. The 3- or 5-year survival rates are indicated on the “3-year survival” line or “5-year survival” line according to their total points. For example, for a patient with CXCL5 positive staining and Dukes II. CXCL5 point is 0, Stage point is 5.2, total point is 5.2, 3-year survival prediction is 78%, 5-year survival prediction is 52%

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