Skip to main content

Advertisement

Table 1 Differences in tumor-VM and ECs-dependent angiogenesis and VM inducer and suppressor molecules

From: Vasculogenic mimicry signaling revisited: focus on non-vascular VE-cadherin

Normal endothelial cells Vasculogenic mimicry cells
Similarities
VE-cadherin positive
E-selectin positive
CD34 positive
Differences
TIE-2 positive TIE-2 negative
VEGFR-1, 2 positive VEGFR-1, 2 negative
P-selectin positive P-selectin negative
VCAM-1/CD106 positive VCAM-1/CD106 negative
CD31/PECAM-1 positive CD31/PECAM-1 negative *13 (Subpopulations PECAM-1 positive melanoma cells)
TIE-1 negative TIE-1 positive
VEGF-C negative VEGF-C positive
Neuropilin 1 negative Neuropilin 1 positive
Endoglin negative Endoglin positive
Tissue factor pathway inhibitor 1 (TFPI1) negative Tissue factor pathway inhibitor 1 (TFPI1) positive
Laminin 5 gamma 2 chain (LAMC2) negative Laminin 5 gamma 2 chain (LAMC2) positive
EphA-2 negative EphA-2 positive