Table 1 Differences in tumor-VM and ECs-dependent angiogenesis and VM inducer and suppressor molecules
From: Vasculogenic mimicry signaling revisited: focus on non-vascular VE-cadherin
Normal endothelial cells | Vasculogenic mimicry cells |
|---|---|
Similarities | |
VE-cadherin positive | |
E-selectin positive | |
CD34 positive | |
Differences | |
TIE-2 positive | TIE-2 negative |
VEGFR-1, 2 positive | VEGFR-1, 2 negative |
P-selectin positive | P-selectin negative |
VCAM-1/CD106 positive | VCAM-1/CD106 negative |
CD31/PECAM-1 positive | CD31/PECAM-1 negative *13 (Subpopulations PECAM-1 positive melanoma cells) |
TIE-1 negative | TIE-1 positive |
VEGF-C negative | VEGF-C positive |
Neuropilin 1 negative | Neuropilin 1 positive |
Endoglin negative | Endoglin positive |
Tissue factor pathway inhibitor 1 (TFPI1) negative | Tissue factor pathway inhibitor 1 (TFPI1) positive |
Laminin 5 gamma 2 chain (LAMC2) negative | Laminin 5 gamma 2 chain (LAMC2) positive |
EphA-2 negative | EphA-2 positive |