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Fig. 1 | Molecular Cancer

Fig. 1

From: SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis

Fig. 1

SOX2 knockdown leads to reduced proliferation of breast cancer cells. a SOX2 knockdown leads to significant reduction in the levels of SOX2 protein in ZR7530 and MDA-MB-231 cells. b SOX2 knockdown inhibits the proliferation of breast cancer cell lines ZR7530 and MDA-MB-231. c Decrease in the levels of SOX2 in breast cancer cells results in reduced colony formation efficiency and colony size. d SOX2 knockdown reduces the levels of cell cycle regulators CDK6, CDK4 and Cyclin D1 (CCND1). * indicates p < 0.05, ** indicates p < 0.01, *** indicates p < 0.001 vs control, and the error bars indicate the mean ± standard deviation (SD)

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