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Fig. 4 | Molecular Cancer

Fig. 4

From: SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis

Fig. 4

Decreased SOX2 levels are associated with reduced expression of miR-181a-5p and miR-30e-5p. a Unsupervised hierarchical cluster analysis of down-regulated miRNAs following SOX2 knockdown. b The decrease in the expression of microRNAs was validated with real-time PCR. Note the levels of miR-30e-5p are decreased most prominent following SOX2 knockdown. c Cellular activities affected by changes in the levels of microRNAs following SOX2 knockdown. d Cellular pathways affected by changes in the levels of microRNAs upon SOX2 knockdown. * indicates p < 0.05, ** indicates p < 0.01, *** indicates p < 0.001 vs control, and the error bars indicate the mean ± standard deviation (SD)

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Molecular Cancer

ISSN: 1476-4598