Fig. 7From: Mesothelin promotes epithelial-to-mesenchymal transition and tumorigenicity of human lung cancer and mesothelioma cellsMSLN regulates EMT and cancer stem cell traits. MSLN knockdown upregulates epithelial and adhesion molecules, and downregulates mesenchymal and CSC regulatory genes that mitigate self-renewal, proliferation, dissemination, and metastasis of cancer cells. Overexpression of MSLN in normal cells stimulates anchorage-independent growth, migration and invasionBack to article page