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Table 1 Cell-surface markers of OCSC

From: Ovarian cancer stem cells: still an elusive entity?

Marker

Biological function

Lowest number of tumorigenic OCSC

References

CD44

HA receptor. Stimulates EGFR-Ras-ERK. Cell proliferation, differentiation, motility, chemoresistance.

102 (CD44+/CD117+)

[76–85]

CD24

Transmembrane glycoprotein. Activates STAT3. Stemness, cell adhesion, tumor cell malignancy, metastasis.

5x103 (CD24+)

[98–103, 105]

CD117

Receptor tyrosine kinase. Regulates PI3K/Akt, Ras/ERK, Src and JAK/STAT pathways. Cell signaling, apoptosis, cell differentiation, proliferation, cell adhesion.

103 (CD117+)

[107–112]

CD133

Transmembrane glycoprotein. Induces PI3K/Akt pathway. CSC maintenance, tumor formation, chemoresistance.

102(CD133+)

[71, 121–124, 131–136]

  1. See the main text for details and additional references
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Molecular Cancer

ISSN: 1476-4598