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Fig. 3 | Molecular Cancer

Fig. 3

From: Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer

Fig. 3

PXR reduces the curative effect of L-OHP on tumor growth in nude mice. a, b The tumor growth curve of PXR-expressing cells was compared with vector-expressing cells after L-OHP treatment. Tumor growth was assessed in nude mice that were subcutaneously injected in the right flank with 5.0 × 106 stable transfectants. Points represent the mean tumor volumes of three independent experiments (n = 3). c, d Tumor weights from the PXR and vector groups were measured. The results were obtained from three independent experiments. *P < 0.05; **P < 0.01. The error bars indicate the s.d. (n = 3). e The tumor growth curve and tumor weights of PXR-expressing cells were compared with vector-expressing cells. The results were obtained from three independent experiments. The error bars indicate the s.d. (n = 3)

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