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Fig. 4 | Molecular Cancer

Fig. 4

From: Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer

Fig. 4

PXR positively correlates with MRP3 expression in colorectal cancer. a Immunohistochemical analysis of PXR and MRP3 expression was performed on cancerous and adjacent noncancerous samples. Low levels of PXR and MRP3 expression were observed in noncancerous tissues compared with cancerous tissues. Scale bars represent 50 μm. Representative samples were shown. b PXR and MRP3 expression levels were analyzed in cancerous and adjacent noncancerous tissues. PXR and MRP3 expression was higher in cancerous tissues than in adjacent noncancerous tissues. The error bars indicate the s.d. c A significant positive correlation between PXR and MRP3 expression was detected in colorectal cancer. The scale bars represent 50 μm. Representative samples were shown. d A significant positive correlation between PXR and MRP3 expression was also observed in two other independent colorectal cancer cohorts from the TCGA database. Heat map was generated to compare PXR and MRP3 expression in the TCGA colorectal cancer gene expression dataset (https://genome-cancer.soe.ucsc.edu/proj/site/xena/heatmap/)

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Molecular Cancer

ISSN: 1476-4598