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Fig. 6 | Molecular Cancer

Fig. 6

From: Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer

Fig. 6

MRP3 is a functionally target gene of PXR in drug resistance. a The expression of PXR and MRP3 was analyzed by WB at 48h after transfecting with MRP3 small interfering RNA (siRNA). The MRP3 siRNA was purchased from Santa Cruz Biotechnology. b Analysis of the effects of L-OHP on cancer cell proliferation when different PXR and MRP3 expression. Cell numbers were counted every day after treatment for 4 days. c Analysis of the effects of L-OHP on cancer cell apoptosis when different PXR and MRP3 expression. d The transport and uptake of L-OHP in tumour cells with different PXR and MRP3 expression were assessed by mass cytometry

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Molecular Cancer

ISSN: 1476-4598