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Fig. 4 | Molecular Cancer

Fig. 4

From: IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis

Fig. 4

IGF2BP3 is a direct target of miR-34a in GC. a The putative miR-34a binding site in 3'UTR of IGF2BP3. b IGF2BP3 mRNA expression was down-regulated by ectopic miR-34a expression in AGS and MKN28 cells (**, P < 0.001). c miR-34a overexpression decreased the IGF2BP3 protein expression in GC cells.. d miR-34a inhibited the luciferase activity of constructs encompassing the wild type binding site, but the luciferase activity in the construct containing mutated binding site in IGF2BP3 3'UTR was not affected (WT, wild type of the complementary sequence for seed region; Mutation, the binding site was mutated; **, P < 0.001). e miR-34a expression in 11 GC cell lines compared with immortalized gastric epithelium cell HFE-145. f Expression of miR-34a in AGS, MKN1, NCI-N87 and MGC-803 cells after treatment with 5-Aza or TSA respectively

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Molecular Cancer

ISSN: 1476-4598