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Fig. 6 | Molecular Cancer

Fig. 6

From: IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis

Fig. 6

Low expression of miR-34a correlates with worse clinical outcome in GC patients. a A lower expression of IGF2BP3 was detected in primary diffuse type of GC compared with intestinal type GC in a published Japanese cohort (E-TABM-341, n = 184, P = 0.008) and TCGA cohort (n = 285, P = 0.008). b The expression of miR-34a in four molecular subtypes of GC (TCGA cohort, n = 295, P < 0.001). c In TCGA cohort, downregulation of miR-34a predicted a shorter overall survival in primary GC samples (P = 0.024). However for recurrence free survival, only an unfavorable trend was detected in low-expression miR-34a group (P = 0.098). d miR-34a expression showed inversely correlated with IGF2BP3 mRNA level in primary samples of TCGA cohort (r = −0.132, n = 277, P = 0.028). In intestinal type GC, the negative correlation was more stringent (r = −0.249, n = 181, P < 0.001)

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