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Fig. 7 | Molecular Cancer

Fig. 7

From: IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis

Fig. 7

IGF2BP3 re-expression partly abrogated the inhibitory effect of miR-34a in GC. a Efficiency of IGF2BP3 re-expression was determined by Western blot. b MTT proliferation assay revealed that re-overexpressed IGF2BP3 partly rescued the growth repression of miR-34a (*, P < 0.05; **, P < 0.001). c Partial restoration of the suppressed cell growth was observed by monolayer colony formation after IGF2BP3 re-overexpression (**, P < 0.001). d Ectopic expression of IGF2BP3 partly recovered the cell invasion ability impaired by miR-34a (**, P < 0.001). e Re-expressed IGF2BP3 in MGC-803 cells partly revive the tumor volume compared with miR-34a group confirmed by in vivo study (*, P < 0.05)

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Molecular Cancer

ISSN: 1476-4598