Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer

Table 1 Clinicopathologic correlation for p-Skp2 expression in GC patients

Factors	All patients	No. of patients		p
	N = 169	p-Skp2 negative	p-Skp2 positive
Age (y)				0.14
<60	84	45	39
≥60	85	36	49
Sex				0.39
Male	121	55	66
Female	48	26	22
Site				0.04
Upper	72	27	45
Middle	25	12	13
lower	72	42	30
Tumor size				0.68
≤4 cm	62	31	31
>4 cm	107	50	57
Pathologic T classification				0.16
T1	17	12	5
T2	32	12	20
T3	41	18	23
T4	79	39	40
Pathologic N status				0.03
N negative	41	26	15
N positive	128	55	73
Pathologic stage (pTNM)				0.02
I	23	17	6
II	45	21	24
III	101	43	58
p-mTOR expression				<0.0005
negative	86	66	20
positive	83	15	68

ISSN: 1476-4598