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Table 2 Exosomes provide potential targets for immunotherapy

From: The emerging roles and therapeutic potential of exosomes in epithelial ovarian cancer

Exo-resource Target cells Effect Potential therapeutic targets Refer.
EOC cells macrophages M2 polarization miR-222-3p [22]
Malignant ascites monocytes cytokine production TLR-dependent signaling pathways [46]
EOC cells NK cells cytotoxicity inhibition NKG2D and DNAM-1 ligands [47]
Malignant ascites PBMCs and DCs apoptosis induction FasL [48]
OC cells T cells counterattack against activated T cells LPA and FasL [50]
Ovarian tumor tissues T cells T cell inhibition depletion or blockade of PS [52]