The emerging roles and therapeutic potential of exosomes in epithelial ovarian cancer

Table 2 Exosomes provide potential targets for immunotherapy

Exo-resource	Target cells	Effect	Potential therapeutic targets	Refer.
EOC cells	macrophages	M2 polarization	miR-222-3p	[22]
Malignant ascites	monocytes	cytokine production	TLR-dependent signaling pathways	[46]
EOC cells	NK cells	cytotoxicity inhibition	NKG2D and DNAM-1 ligands	[47]
Malignant ascites	PBMCs and DCs	apoptosis induction	FasL	[48]
OC cells	T cells	counterattack against activated T cells	LPA and FasL	[50]
Ovarian tumor tissues	T cells	T cell inhibition	depletion or blockade of PS	[52]

ISSN: 1476-4598