From: The emerging roles and therapeutic potential of exosomes in epithelial ovarian cancer
Exo-function | Exo-resource | Mechanism | Potential therapeutic targets | Refer. |
---|---|---|---|---|
Proliferation | OSA | miR-30a-5p is an oncogenic miRNA | miR-30a-5p | [26] |
malignant ascites | exosomes contain tumor progression-related proteins | EMMPRIN/CD147 pro-heparanase | [51] | |
Invasion/Migration/Metastasis | Invasive tumor cell lines. bodily fluids of OC patients | VAMP3 regulates the delivery MT1-MMP in exosomes | MT1-MMP | [58] |
malignant ovarian ascites | increased extracellular matrix degradation | MMPs and uPA | [59] | |
OC cell lines (CABA I and A2780) | proteolytic activity | MMPs | [60] | |
ovarian carcinoma cell lines malignant ascites | L1 is cleaved by ADAM10 | L1 adhesion molecule (CD171) | [61] | |
OC cell line (IGROV1) | increases genes involved in the EMT | LIN28 | [62] | |
OC patients | educate mesothelial cells to allow dissemination | miRNAs in exosomes | [63] | |
OC cell lines (Skov-3 and OVCaR-3) | miR-let-7 suppresses cell proliferation miR-200 suppresses the EMT | miR-let-7 miR-200 | [64] | |
Intracellular communication | OC and cirrhotic ascites | signal transduction | cluster of spliceosomal proteins and RNAs | [65] |
ovarian cell lines (OVCA429 and HO8910PM) | pentose phosphate pathway | G6PD, TK, TA1 | [40] | |
Angiogenesis | OC cell lines | affect VEGF or HIF-1α | ATF2 and MTA1 | [27] |
ovarian carcinoma cells | CD147 stimulates VEGF expression | CD147 | [68] | |
SKOV3 cells | down-regulate IGF1R | miR-375 | [69] |