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Table 3 Exosomes related to tumor progression, metastasis and angiogenesis

From: The emerging roles and therapeutic potential of exosomes in epithelial ovarian cancer

Exo-function Exo-resource Mechanism Potential therapeutic targets Refer.
Proliferation OSA miR-30a-5p is an oncogenic miRNA miR-30a-5p [26]
malignant ascites exosomes contain tumor progression-related proteins EMMPRIN/CD147 pro-heparanase [51]
Invasion/Migration/Metastasis Invasive tumor cell lines. bodily fluids of OC patients VAMP3 regulates the delivery MT1-MMP in exosomes MT1-MMP [58]
malignant ovarian ascites increased extracellular matrix degradation MMPs and uPA [59]
OC cell lines (CABA I and A2780) proteolytic activity MMPs [60]
ovarian carcinoma cell lines malignant ascites L1 is cleaved by ADAM10 L1 adhesion molecule (CD171) [61]
OC cell line (IGROV1) increases genes involved in the EMT LIN28 [62]
OC patients educate mesothelial cells to allow dissemination miRNAs in exosomes [63]
OC cell lines (Skov-3 and OVCaR-3) miR-let-7 suppresses cell proliferation miR-200 suppresses the EMT miR-let-7 miR-200 [64]
Intracellular communication OC and cirrhotic ascites signal transduction cluster of spliceosomal proteins and RNAs [65]
ovarian cell lines (OVCA429 and HO8910PM) pentose phosphate pathway G6PD, TK, TA1 [40]
Angiogenesis OC cell lines affect VEGF or HIF-1α ATF2 and MTA1 [27]
ovarian carcinoma cells CD147 stimulates VEGF expression CD147 [68]
SKOV3 cells down-regulate IGF1R miR-375 [69]