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Table 3 Exosomes related to tumor progression, metastasis and angiogenesis

From: The emerging roles and therapeutic potential of exosomes in epithelial ovarian cancer

Exo-function

Exo-resource

Mechanism

Potential therapeutic targets

Refer.

Proliferation

OSA

miR-30a-5p is an oncogenic miRNA

miR-30a-5p

[26]

malignant ascites

exosomes contain tumor progression-related proteins

EMMPRIN/CD147 pro-heparanase

[51]

Invasion/Migration/Metastasis

Invasive tumor cell lines. bodily fluids of OC patients

VAMP3 regulates the delivery MT1-MMP in exosomes

MT1-MMP

[58]

malignant ovarian ascites

increased extracellular matrix degradation

MMPs and uPA

[59]

OC cell lines (CABA I and A2780)

proteolytic activity

MMPs

[60]

ovarian carcinoma cell lines malignant ascites

L1 is cleaved by ADAM10

L1 adhesion molecule (CD171)

[61]

OC cell line (IGROV1)

increases genes involved in the EMT

LIN28

[62]

OC patients

educate mesothelial cells to allow dissemination

miRNAs in exosomes

[63]

OC cell lines (Skov-3 and OVCaR-3)

miR-let-7 suppresses cell proliferation miR-200 suppresses the EMT

miR-let-7

miR-200

[64]

Intracellular communication

OC and cirrhotic ascites

signal transduction

cluster of spliceosomal proteins and RNAs

[65]

ovarian cell lines (OVCA429 and HO8910PM)

pentose phosphate pathway

G6PD, TK, TA1

[40]

Angiogenesis

OC cell lines

affect VEGF or HIF-1α

ATF2 and MTA1

[27]

ovarian carcinoma cells

CD147 stimulates VEGF expression

CD147

[68]

SKOV3 cells

down-regulate IGF1R

miR-375

[69]