From: The emerging roles and therapeutic potential of exosomes in epithelial ovarian cancer
Exo-source | Specific source | Content | Drugs | Target/Mechanism | Refer. |
---|---|---|---|---|---|
cancer-related cells | CAAs or CAFs | miR21 | paclitaxel | APAF1 | [71] |
cancer cells | A2780 cells | miR-433 | paclitaxel | CDK6 | [72] |
A2780 (PTX/WT) cells | P-gp | paclitaxel | export chemotherapeutic agents | [74] | |
A2780 and CP70 cells | miR-21-3p | carboplatin | NAV3 gene | [73] | |
sera from OC patients SKOV3/CIS cells | annexin A3 | carboplatin | prevent uptake or accumulation of platinum in cells | [76] | |
CIS-resistant cells | ATP7A, ATP7B | carboplatin | CIS-export transporters | [77] |