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Fig. 2 | Molecular Cancer

Fig. 2

From: Combination of paclitaxel, bevacizumab and MEK162 in second line treatment in platinum-relapsing patient derived ovarian cancer xenografts

Fig. 2

Antitumor activity of the combination of PTX, bevacizumab and MEK162 in MNHOC218 PDX model. Xenograft MNHOC218 was transplanted subcutaneously and when tumor masses reached 100-150mg, mice were randomized to receive vehicle (CTR,-♦-), or treated with Bevacizumab and MEK162 (BEV/MEK,-■-), paclitaxel and MEK162 (PTX/MEK,-▲-), paclitaxel and bevacizumab (PTX/BEV, --), or paclitaxel and bevacizumab and MEK162 (PTX/BEV/MEK,-x-). Data are the mean ± SE of tumor masses, as described in Materials and Methods; each group consisted of 8-10 mice

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