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Fig. 1 | Molecular Cancer

Fig. 1

From: MicroRNA-608 inhibits proliferation of bladder cancer via AKT/FOXO3a signaling pathway

Fig. 1

miR-608 is down-regulated in BCa and regulated by DNA methylation. a The relative expression levels of miR-608 in 13 pairs of BCa tissues were presented as the fold change of miR-608 referred to the corresponding normal tissues. b Representative CISH staining of miR-608 in TMA. c Statistical analysis indicated that the expression levels of miR-608 in BCa tissues were significantly higher than those in adjacent non-tumor tissues in TMA. d The relative miR-608 levels in BCa cell lines (T24 and UM-UC-3) compared with non-tumor urothelial cell line (SV-HUC-1). e The DNA sequence of CpG island in miR-608 promoter analyzed by BSP. f In contrast with DMSO, demethylation agent 5-aza-dC stimulated the expression of miR-608 in BCa cell lines (T24 and UM-UC-3). Error bars represent the S.D. from three independent experiments. g and h Methylation profile in T24 and UM-UC-3 cell lines. The open and filled circles symbolized the unmethylated and methylated CpGs respectively. Ten colonies from each cell line were analyzed. Error bars represent the S.D. from ten randomly chosen colonies. *P < 0.05

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