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Fig. 3 | Molecular Cancer

Fig. 3

From: Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma

Fig. 3

Loss of Tgfbr1 and Pten in murine epithelia induces extracellular adenosine pathway activation. a Representative pictures of HIF-1α, CD73 and A2AR immunohistochemical staining of normal tongue mucosa from wild type (WT) mice and HNSCC from Tgfbr1 and Pten double conditional knockout (2cKO) tumor bearing mice (each group n = 6, left, scale bar = 100 μm). b The digital quantification of the histoscore of HIF-1α, CD73 and A2AR. The expression of HIF-1α, CD73 and A2AR was significantly elevated in the tumor from 2cKO mice as compared with the normal tongue mucosa from the WT mice (Mean ± SEM, ***, P < 0.001, unpaired t test). c Western blot indicated that combined deletion of Tgfbr1 and Pten in head and neck epithelial obviously elevated the protein level of HIF-1α, CD73 and A2AR. GAPDH was used as loading control

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