Skip to main content
Fig. 5 | Molecular Cancer

Fig. 5

From: Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma

Fig. 5

Pharmacological blockade of A2AR delays tumor growth in HNSCC mouse model. a Schematic representation of tamoxifen oral gavage and SCH58261 treatment of the spontaneous HNSCC mouse model. b Representative photos of tumor (yellow arrowhead) in mice treated with DMSO (Vehicle, left) or SCH58261 (right) at day 19 and day 34 after tamoxifen oral gavage. c The A2AR inhibition efficiency was tested by western blotting (GAPDH was used as loading control). SCH58261 treatment obviously decreased the protein level of A2AR in the lysis of the tumor. d Tumor volumes over time of vehicle group and SCH58261 treated group (n = 6, each group). The statistical significance reached since day 25(Mean ± SEM, * P < 0.05, **, P < 0.01, ***, P < 0.001). e Drug toxicity was presented as increased body weight of the mice in vehicle group and SCH58261 treated group (ns = no significance, unpaired t test)

Back to article page

Molecular Cancer

ISSN: 1476-4598