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Table 1 The correlation of A2AR expression with clinicopathologic parameters in HNSCC

From: Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma

Parameters

No.

Mean ± SEM

P value

Norma Mucosa

43

23.97 ± 4.106

Mucosa vs. Dys 0.9522

Dysplasia (Dys)

48

28.52 ± 4.661

Mucosa vs. PH < 0.001

Primary HNSCC (PH)

165

104.8 ± 6.823

Dys vs. PH < 0.001

Grade

 I

43

49.84 ± 9.083

I vs. II < 0.001

 II

84

115.8 ± 9.275

I vs. III < 0.001

 III

38

142.8 ± 15.00

II vs. III 0.2093

Lymph node involvement

 N0

105

85.53 ± 7.646

<0.001

 N1 + N2

60

138.6 ± 12.05

 

Tumor Size

 T1 + T2

115

91.07 ± 7.109

0.002

 T3 + T4

50

136.5 ± 14.65

 

Gender

 Male

129

104.7 ± 7.607

0.9610

 Female

36

105.5 ± 15.54

 

Age

  < 50

44

98.84 ± 14.59

0.5976

  ≥ 50

121

107.0 ± 7.672

 

HPV infection

 Negative

149

102.0 ± 7.011

0.2017

 Positive

16

131.5 ± 26.08

 

 Primary HNSCC (PH)

165

104.8 ± 6.823

(reference)

 Recurrent HNSCC (Recurrence)

12

170.2 ± 28.35

0.0144

 HNSCC with inductive TPF chemotherapy (post TPF)

17

165.5 ± 18.40

0.0066

  1. Difference among three groups was analyzed by One-way ANOVO followed Tukey test. Difference between two groups was analyzed by un-paired or paired t test