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Fig. 3 | Molecular Cancer

Fig. 3

From: Antagonizing miR-455-3p inhibits chemoresistance and aggressiveness in esophageal squamous cell carcinoma

Fig. 3

Inhibition of miR-455-3p chemosensitizes ESCC cells and reduces stem cell-like traits. a Representative tumor growth curves of xenografts derived from CDDP-resistant ESCC cells co-treated with CDDP (5 mg/kg) and antagomir-control or with CDDP (5 mg/kg) and antagomir-455-3p on the indicated days (left). To establish the contribution of miR-455-3p, antagomir-455-3p treatment was stopped on Day 34, but CDDP treatment was continued (right). b The frequency of T-ICs in the indicated cells. c Representative images (left) and quantification (right) of tumorspheres formed by the indicated cells. d, e Flow cytometry analysis of the percentages of the CD90+ and CD271+ subpopulations (d) and SP (e) of the indicated cells. Each bar represents the mean ± SD of three independent experiments. * P < 0.05

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