Fig. 10

Expression relations amongst the sub-clusters and signatures in cell line and clinical datasets. Part a shows that in the 16 cell-line datasets, when hypoxia occurs, C1 sub-clusters are repressed while C2 sub-clusters are up-regulated. The 51-gene and the 20-gene signatures were previously established as signatures of hypoxia, and they are indeed up-regulated under hypoxia. Parts b to (g) show the gene expression relations amongst the different sub-clusters or signatures in each one of the six considered clinical datasets. Also, the ER status is included where its information is available. For example, b shows that in the TCGA dataset, when ER is down (negative), C2a genes go down in expression, while the expression of the genes in C1b, C2b, and the 51-gene and 20-gene signatures go up