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Table 6 TFs with significant enrichment in the clusters C1 and C2 as well as their sub-clusters

From: In vitro downregulated hypoxia transcriptome is associated with poor prognosis in breast cancer

Cluster

TF

Adjusted CSa

Number of genes

Cluster

TF

Adjusted CSa

Number of genes

C1

  

504

C2

  

598

MYC

7.9

217

 

HIF1A

9.4

70

EKLF

7.5

118

C2a

  

204

JARID1A

6.7

146

C2b

  

88

ETS1

5.9

115

 

HIF1A

9.7

16

C1a

  

116

C2c

  

168

KDM5B

8.1

70

 

HIF1A

9.2

24

MYC

6.7

58

51-gene sig.b

  

51

C1b

  

273

 

HIF1A

17.2

17

MYC

10.1

125

20-gene sig.b

  

20

EKLF

9.0

77

 

HIF1A

10.1

8

JARID1A

9.0

99

 

TRIM28

6.2

3

ETS1

8.2

80

    

HOXC9

5.6

75

    

GABP

5.3

87

    
  1. aThe adjusted combined score (CS) calculation is detailed in Additional file 7 where the complete Table is. Only TFs with adjusted CS higher than the threshold of 5.0 are included here
  2. bThe 51-gene and the 20-gene signatures are hypoxia-induced signatures identified in [5] and [24] respectively
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Molecular Cancer

ISSN: 1476-4598