Fig. 5

Clinical significances of Oct4/NEAT1/MALAT1 signaling axis in 124 lung cancer patients. qRT-PCR analyses of Oct4, NEAT1 and MALAT1 RNA expression were performed in 124 lung cancer specimens. a-d Overall survival analyzed by Kaplan-Meier method indicated that patients with high RNA expression of Oct4 (a), NEAT1 (b), MALAT1 (c) or coinciding high expression of Oct4, NEAT1 and MALAT1 (d) had poor survival. P-values were determined using log-rank test. e Schematic diagram depicting Oct4 activates NEAT1 transcription via promoter binding and MALAT1 transcription via enhancer binding. NEAT1 and MALAT1 lncRNAs act as downstream effectors of Oct4 to promote lung cancer proliferation, migration and invasion, and thereby lead to lung cancer progression