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Fig. 5 | Molecular Cancer

Fig. 5

From: MicroRNA-1296 inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting SRPK1-mediated PI3K/AKT pathway

Fig. 5

Modulation of SRPK1 partially abolishes miR-1296-mediated cellular processes in HCC. a miR-1296-overexpressing HCCLM3 cells that were transfected with empty vector (EV) or SRPK1 overexpression plasmid were subjected to western blot for SRPK1. b SRPK1 restoration promoted migration and invasion of miR-1296-overexpressing HCCLM3 cells. c miR-1296-suppressive Hep3B cells that were transfected with scrambled siRNA or SRPK1 siRNA were subjected to western blot for SRPK1. d SRPK1 knockdown abrogated the effects of miR-1296 loss on migration and invasion of Hep3B cells. e SRPK1 restoration decreased the expression of E-cadherin and increased the levels of N-cadherin and Vimentin in miR-1296 overexpressing HCCLM3 cells. f SRPK1 knockdown abolished the effects of miR-1296 loss on EMT process of Hep3B cells. *P < 0.05

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Molecular Cancer

ISSN: 1476-4598