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Fig. 9 | Molecular Cancer

Fig. 9

From: MicroRNA-1296 inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting SRPK1-mediated PI3K/AKT pathway

Fig. 9

miR-1296 mediates the promoting effects of hypoxia on metastasis and EMT of HCC cells. a The expressions of HIF-1α in different time points in normoxia and hypoxia condition. b The levels of miR-1296 in Hep3B cells cultured in normoxia and hypoxia. c Transwell assays revealed that hypoxia promoted migration and invasion of Hep3B cells, while miR-1296 overexpression abolished the effects of hypoxia. d Hypoxia facilitated the EMT process of Hep3B cells and miR-1296 restoration showed a opposite effect. *P < 0.05, **P < 0.01

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Molecular Cancer

ISSN: 1476-4598