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Fig. 1 | Molecular Cancer

Fig. 1

From: STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4

Fig. 1

HOXD-AS1 is upregulated and positively associated with poor prognosis in HCC patients. a Hierarchical clustering analysis of 26 lncRNAs that were differentially expressed in 14 paired samples of cancerous tissues (c) and corresponding adjacent noncancerous liver tissues (N) (fold change > 22 or <2-2, p < 0.05). Expression values are represented in shades of red and green. b The fold change of HOXD-AS1 expression in 14 HCC tissues (probe: 228601_at). c Left: HOXD-AS1 expression in 89 paired samples of HCC tissues (p < 0.0001). Right: Pie chart of the proportions of HCC samples in which HOXD-AS1 expression was upregulated (blue), downregulated (red), or showed no change (green). d Correlation between HOXD-AS1 expression and overall survival in 120 HCC patients. Median value of HOXD-AS1 expression was chosen as the point for separating tumors with low or high-level expression group. (Log-rank; p = 0.0179). e The expression levels of HOXD-AS1 in nuclear and cytoplasm of HCC cells. U1 (nuclear retained) and GAPDH (exported to cytoplasm) were used as controls. f Fluorescence in situ hybridization analysis of the subcellular location of HOXD-AS1 in HCC cells

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